Premium
Synthesis of 1,2,3,4‐tetrahydroquinazoline derivatives as potential alpha ‐adrenergic blocking agents
Author(s) -
Granados R.,
Alvarez M.,
Vails N.,
Salas M.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200525
Subject(s) - chemistry , cystamine , thiazolidine , alpha (finance) , blocking (statistics) , stereochemistry , condensation , chloride , tropolone , medicinal chemistry , organic chemistry , biochemistry , medicine , construct validity , statistics , nursing , mathematics , physics , patient satisfaction , thermodynamics
The synthesis of N,N ′‐bis[6‐(1,2,3,4‐tetrahydro‐3‐quinazolidyl)hexyl]cystamine (I) and 3‐(6‐aminohexyl)‐1,2,3,4‐tetrahydroquinazoline (II) are described. Compound I is obtained by condensation of o ‐nitrobenzoyl chloride with 3‐(6‐aminohexyl)‐1,3‐thiazolidine (III) followed by dimerization, reduction and formation of tetrahydroquinazoline ring. A similar method was used for preparation of compound II. These compounds and some synthesis intermediates are potential alpha ‐adrenergic blockers.