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Synthesis of 6‐methoxy‐2,2‐dimethyl‐2 H ‐1‐benzothiopyran and 6,7‐dimethoxy‐2,2‐dimethyl‐2 H ‐1‐benzothiopyran, sulfur analogues of precocene I and precocene II
Author(s) -
Camps F.,
Colomina O.,
Coll J.,
Messeguer A.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200456
Subject(s) - chemistry , thiophenol , sulfur , organic chemistry , dehydration , combinatorial chemistry , medicinal chemistry , biochemistry
Preparation of title compounds 5 , sulfur analogues of the natural insect antijuvenile hormones precocene I and II, is described. The synthetic pathway involves conversion of the appropriate thiophenol 2 into the corresponding thiochroman‐4‐one 4 followed by reduction and dehydration. The 13 C nmr data for all the above products are also reported.