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The synthesis and characterisation of some 2,7‐diazaphenanthrene derivatives
Author(s) -
Gill E. W.,
Bracher A. W.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200453
Subject(s) - chemistry , oleum , yield (engineering) , ring (chemistry) , closure (psychology) , medicinal chemistry , stereochemistry , organic chemistry , materials science , economics , metallurgy , market economy
Abstract 2,7‐Diazaphenanthrene was synthesised in moderate yield by the modified Pomeranz‐Fritsch reaction by condensing diethoxyethanal with 1,4‐benzenebismethanamine, followed by ring closure with 20% oleum, and its spectral characteristics recorded. A similar reaction with diethyl 1,4‐benzenebis(3‐aminopropanoate) gave either 2,7‐diaza‐1,8‐dimethylphenanthrene or 2,7‐diaza‐1,8‐phenanthrenebis(methylsulphonic acid), depending on the conditions of the ring closure reaction. The bis methiodides of these compounds were tested for phospholipase A 2 inhibitory action but were found to be inactive.