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Reaction of 2‐acetamido‐3,7‐dihydropyrrolo[2,3‐ d ]pyrimidin‐4‐one with dimethylamine and formaldehyde. Formation of two isomeric mannich bases
Author(s) -
Benghiat Eric,
Crooks Peter A.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200436
Subject(s) - dimethylamine , chemistry , formaldehyde , acetic acid , mannich reaction , medicinal chemistry , methylamine , organic chemistry , catalysis
2‐Acetamido‐3, 7‐dihydropyrrolo[2, 3‐ d )pyrimidin‐4‐one reacts with dimethylamine and formaldehyde in glacial acetic acid to afford the two isomeric Mannich products, 2‐acetamido‐3, 7‐dihydro‐5‐dimethylamino‐methylpyrrolo[2, 3‐ d ]pyrimidin‐4‐one, and 2‐acetamido‐3, 7‐dihydro‐6‐dimethylaminomethylpyrrolo[2, 3‐ d ]‐pyrimidin‐4‐one, in a ratio of 3:1, respectively.