Reaction of 3‐hetero‐substituted 2‐phenyl‐4‐thioxo‐3,4‐dihydro‐quinazolines with acyl chlorides and phenacyl bromides | Zendy

Molina P. | Zendy; Arques A. | Zendy; Cartagena I. | Zendy; Noguera J. A. | Zendy; Valcarcel M. V. | Zendy

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Reaction of 3‐hetero‐substituted 2‐phenyl‐4‐thioxo‐3,4‐dihydro‐quinazolines with acyl chlorides and phenacyl bromides

Author(s) -

Molina P.,

Arques A.,

Cartagena I.,

Noguera J. A.,

Valcarcel M. V.

Publication year - 1983

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570200427

Subject(s) - chemistry , phenacyl , acetonitrile , medicinal chemistry , dimethylformamide , phenyl isothiocyanate , thiadiazoles , organic chemistry , solvent

Some 2, 5‐disubstituted 1, 3, 4‐thiadiazoles 5 were obtained by reaction of 3‐amino‐2‐phenyl‐4‐thioxo‐3, 4‐dihydroquinazoline ( 1 ) with acyl chlorides. Reaction of 3‐hydroxy‐2‐phenyl‐3, 4‐dihydroquinazoline ( 3 ) with phenacyl bromides was carried out either in dry acetonitrile or dimethylformamide to give 2‐phenyl‐4‐phenacylthio‐3‐quinazolinium N ‐oxides 7 or 2‐phenyl‐4‐phenacylidene‐1 H ‐3‐quinazolinium N ‐oxides' 8 , respectively.

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