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Reaction of 3‐hetero‐substituted 2‐phenyl‐4‐thioxo‐3,4‐dihydro‐quinazolines with acyl chlorides and phenacyl bromides
Author(s) -
Molina P.,
Arques A.,
Cartagena I.,
Noguera J. A.,
Valcarcel M. V.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200427
Subject(s) - chemistry , phenacyl , acetonitrile , medicinal chemistry , dimethylformamide , phenyl isothiocyanate , thiadiazoles , organic chemistry , solvent
Some 2, 5‐disubstituted 1, 3, 4‐thiadiazoles 5 were obtained by reaction of 3‐amino‐2‐phenyl‐4‐thioxo‐3, 4‐dihydroquinazoline ( 1 ) with acyl chlorides. Reaction of 3‐hydroxy‐2‐phenyl‐3, 4‐dihydroquinazoline ( 3 ) with phenacyl bromides was carried out either in dry acetonitrile or dimethylformamide to give 2‐phenyl‐4‐phenacylthio‐3‐quinazolinium N ‐oxides 7 or 2‐phenyl‐4‐phenacylidene‐1 H ‐3‐quinazolinium N ‐oxides' 8 , respectively.