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Facile synthesis of N ‐substituted‐4‐cyano‐4‐phenylpiperidines via phase‐transfer catalysis
Author(s) -
Thompson Doug,
Reeves Perry C.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200350
Subject(s) - chemistry , catalysis , bromide , sodium hydroxide , phase (matter) , phase transfer catalyst , aqueous solution , sodium bromide , hydroxide , medicinal chemistry , combinatorial chemistry , organic chemistry , sodium
Phenylacetonitrile can be condensed with N ‐substituted‐bis(2‐chloroethyl)amines in aqueous sodium hydroxide solution to produce N ‐substituted‐4‐cyano‐4‐phenylpiperidines. Hexadecyltributylphosphonium bromide is an effective catalyst for this phase‐transfer reaction.