Synthesis of 2‐arylpyrido[3,4‐ b ]pyrazine derivatives through condensation of 3,4‐diaminopyridine with β‐keto sulfoxides | Zendy

Kano Shinzo | Zendy; Yuasa Yoko | Zendy

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Synthesis of 2‐arylpyrido[3,4‐ b ]pyrazine derivatives through condensation of 3,4‐diaminopyridine with β‐keto sulfoxides

Author(s) -

Kano Shinzo,

Yuasa Yoko

Publication year - 1983

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570200349

Subject(s) - pyrazine , chemistry , condensation , acetic acid , benzene , medicinal chemistry , stereochemistry , organic chemistry , physics , thermodynamics

The reaction between 3,4‐diaminopyridine and α‐methylsulfinylacetophenone in benzene containing acetic acid under reflux gave 2‐phenylpyrido[3,4‐ b ]pyrazine. In this way, 2‐(4‐methoxyphenyl)pyrido[3,4‐ b ]‐pyrazine and 2‐(3,4‐dimethoxyphenyl)pyrido[3,4‐ b ]pyrazine were obtained by condensation of 3,4‐diaminopyridine with the corresponding α‐methylsulfinylacetophenones.

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