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Synthesis of 2‐arylpyrido[3,4‐ b ]pyrazine derivatives through condensation of 3,4‐diaminopyridine with β‐keto sulfoxides
Author(s) -
Kano Shinzo,
Yuasa Yoko
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200349
Subject(s) - pyrazine , chemistry , condensation , acetic acid , benzene , medicinal chemistry , stereochemistry , organic chemistry , physics , thermodynamics
The reaction between 3,4‐diaminopyridine and α‐methylsulfinylacetophenone in benzene containing acetic acid under reflux gave 2‐phenylpyrido[3,4‐ b ]pyrazine. In this way, 2‐(4‐methoxyphenyl)pyrido[3,4‐ b ]‐pyrazine and 2‐(3,4‐dimethoxyphenyl)pyrido[3,4‐ b ]pyrazine were obtained by condensation of 3,4‐diaminopyridine with the corresponding α‐methylsulfinylacetophenones.