Studies related to the total synthesis of pentostatin. Approaches to the synthesis of (8 R )‐3,6,7,8‐tetrahydroimidazo‐[4,5‐ d ][1,3]diazepin‐8‐ol and  N ‐3 alkyl congeners | Zendy

Baker David C. | Zendy; Putt Sterling R. | Zendy; Showalter H. D. Hollis | Zendy

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Studies related to the total synthesis of pentostatin. Approaches to the synthesis of (8 R )‐3,6,7,8‐tetrahydroimidazo‐[4,5‐ d ][1,3]diazepin‐8‐ol and N ‐3 alkyl congeners

Author(s) -

Baker David C.,

Putt Sterling R.,

Showalter H. D. Hollis

Publication year - 1983

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570200324

Subject(s) - chemistry , imidazole , pentostatin , nitro , ring (chemistry) , stereochemistry , alkyl , medicinal chemistry , organic chemistry , enzyme , adenosine deaminase

A number of synthetic approaches to the (8 R )‐3,6,7,8‐tetrahydroimidazo[4,5‐ d ][1,3]diazepin‐8‐ol ring system ( 3 ) of pentostatin ( 1 ) are reported. These involve the synthesis of a number of 4‐ C ‐derivatives of N ‐alkyl‐5‐amino‐ and 5‐nitro‐1 H ‐imidazoles derived from 4‐methyl‐5‐nitro‐1 H ‐imidazole.

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