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Synthesis of some pyrrolobenzothiazepines via N ‐aryl‐2‐thiocyanatopyrroles
Author(s) -
Cheeseman G. W. H.,
Hawi A. A.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200317
Subject(s) - chemistry , aryl , pyrrole , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , alkyl
Pyrrolo[1,2‐ a [3,1]benzothiazepines were successfully synthesized from alkylthiopyrroles. The latter compounds were prepared from the appropriate N ‐aryl‐2‐thiocyanopyrroles. 2,3‐Dihydro‐3‐oxo‐4‐phenylthieno[3,2‐ b ]pyrrole ( 29 ) was obtained from acid treatment of the 2‐pyrrolylthioacetic acid 28 .