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Quinazolines and 1,4‐benzodiazepines. XCIII. Synthesis of imidazo[1,5‐ a ][1,4]benzodiazepines from nitrooximes
Author(s) -
Walser A.,
Fryer R. Ian
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200313
Subject(s) - chemistry , nucleophile , nitro , amine gas treating , tertiary amine , medicinal chemistry , stereochemistry , organic chemistry , catalysis , alkyl
The displacement of the nitro group in nitrooximes by other nucleophiles was used to prepare various 2‐(hydroxyimino)methyl‐ and 2‐(methoxyimino)methyl‐1,4‐benzodiazepines. These compounds were converted to imidazo[1,5‐ a ][1,4]benzodiazepines bearing a tertiary amine, methoxy or thiomethyl group in the 3‐position.