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Synthesis and evaluation of AChE inhibitory activity of 5,6‐diaryl‐1,2,4‐triazinyloxyacetyl‐4‐substituted thiosemicarbazides, triazoles and N ‐benzylidene derivatives
Author(s) -
Sen Gupta Anil K.,
Hajela Kanchan,
Bhattacharya Tapas,
Ahmad Shakeel,
Shanker Kripa
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200303
Subject(s) - chemistry , hydrazine (antidepressant) , cholinesterase , condensation , medicinal chemistry , ring (chemistry) , aryl , triazole , organic chemistry , chromatography , pharmacology , thermodynamics , medicine , physics , alkyl
A series of 1,2,4‐triazinyl thiosemicarbazides, triazoles and N ‐benzylidene derivatives have been synthesized by condensation of 5,6‐diphenyl‐1,2,4‐triazin‐3‐yloxyacetyl hydrazine with aromatic aldehydes and aryl isothiocyanates. Subsequent ring closure of thiosemicarbazides yielded the triazoles. All the compounds were subjected to in vitro testing of cholinesterase inhibitory action. Percentage inhibition was found to be moderate to good in a few of the compounds.