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Identification of the nitrosation reaction products of alkyl esters of 1,2‐benzisoxazole‐3‐acetic acid by chemical and crystallographic methods
Author(s) -
Giannella Mario,
Gualtieri Fulvio,
Fedeli Walter,
Cerrini Silvio,
Gavuzzo Enrico
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200223
Subject(s) - chemistry , acetic acid , nitrosation , nitrite , alkyl , organic chemistry , carboxylic acid , crystal structure , amyl nitrite , medicinal chemistry , nitrate , medicine , anesthesia
The reaction between methyl or ethyl esters of 1, 2‐benzisoxazole‐3‐acetic acid and iso ‐amyl nitrite is reported. The main product is identified as 4‐(2′‐hydroxyphenyl)furazan‐3‐carboxylic acid ( 4 ) by chemical and X‐ray crystal structure analyses. The synthesis of esters of E ‐ and Z ‐α‐(hydroxyimino)‐1, 2‐benzisoxazole‐3‐acetic acid is also reported.