Premium
Reaction of tetrachloropyrazine with active methylene compounds
Author(s) -
Tong Y. C.,
Kerlinger H. O.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200220
Subject(s) - chemistry , alkylation , diethyl malonate , ethyl acetoacetate , methylene , ring (chemistry) , malonate , keto–enol tautomerism , medicinal chemistry , carbanion , organic chemistry , catalysis , tautomer
When tetrachloropyrazine was allowed to react with the anions formed from diethyl malonate and malonitrile, the normal alkylation took place. When the anions from ethyl acetoacetate and N,N ‐diethylacetoacetamide were used, alkylation was followed by enolization and ring formation to give furo [2,3‐ b ] pyrazines. The structure proof and reaction of the furo [2,3‐ b ] pyrazines are discussed.