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Synthesis of 6‐methoxyindoles and indolines. Regioselective c‐6 bromination of indolines and subsequent nucleophilic substitution with a methoxyl group
Author(s) -
Miyake Yuko,
Kikugawa Yasuo
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200217
Subject(s) - regioselectivity , chemistry , bromine , halogenation , superacid , sulfuric acid , nucleophile , nucleophilic substitution , organic chemistry , medicinal chemistry , substitution reaction , catalysis
Regioselective bromination of the 6‐position of indolines was investigated. Treatment of indolines with bromine in sulfuric acid in the presence of silver sulfate or with bromine in superacid afforded the 6‐bromoindolines, which were converted to 6‐methoxyindolines and indoles.