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Synthesis of some pyridylamino‐1,4‐disubstituted phthalazines
Author(s) -
Bautista Dorothy V.,
Bullock Graham,
Hartstock Frederick W.,
Thompson Laurence K.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200216
Subject(s) - chemistry , phthalonitrile , phthalazine , hydrazine (antidepressant) , condensation , ring (chemistry) , organic chemistry , medicinal chemistry , polymer chemistry , phthalocyanine , physics , chromatography , thermodynamics
Two general procedures involving the condensation of phthalonitrile or 1,3‐diiminoisoindoline with various aminopicolines, followed by ring expansion with hydrazine to the corresponding phthalazine are described. Syntheses are reported of 1, 4‐di(3′‐methyl‐2′‐pyridyl) aminophthalazine, 1,4‐di(5′‐methyl‐2′‐pyridyl)aminophthalazine, and 1,4‐di(4′, 6′‐dimethyl‐2′‐pyridyl)aminophthalazine.