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Preparation of 7‐substituted pyrrolo [2,3‐ d ] pyrimidines and 9‐substituted purines as potential antiparasitic agents
Author(s) -
LaMontagne Maurice P.,
Smith David C.,
Wu GengShuen
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200208
Subject(s) - chemistry , purine metabolism , antiparasitic , antiparasitic agent , stereochemistry , bicyclic molecule , combinatorial chemistry , pharmacology , biochemistry , enzyme , medicine , pathology
A series of six 7‐substituted pyrrolo [2, 3‐ d ] pyrimidines and two 9‐substituted purines were prepared and evaluated for potential antiparasitic activity. All were inactive against P. berghei in mice. Six of the target compounds were also evaluated for antitrypanosomal activity against T. rhodesiense in mice. All six compounds were also inactive in this screen.