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A novel synthesis of fused imidazo[5,1‐ c ]‐1,2,4‐triazoles
Author(s) -
Abd Allah Sanaa O.,
Ead Hamed A.,
Kassab Nazmi A.,
Zayed Mohey M.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200139
Subject(s) - chemistry , phenacyl bromide , benzylamine , ethyl bromoacetate , alkylation , phenacyl , bromide , phenylhydrazine , alkyl , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis
The new fused imidazo[5,1‐ c ]‐1,2,4‐triazoles 4 were obtained by cyclization of the corresponding 2‐imidazolidinone 4‐phenylhydrazones 2 which were obtained by the action of phenylhydrazine on the arylmethylene derivatives of 4‐thioxo‐2‐imidazolidinone 1 . The benzylimino derivatives 6 were obtained by the reaction of benzylamine with 1 . Alkylation of 1 with phenacyl bromide and/or ethyl bromoacetate afforded the S ‐alkyl derivatives 7.