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4‐(2‐di‐ n ‐propylaminoethyl)‐7‐methoxyindole
Author(s) -
Can Joseph G.,
Lukszo Jan,
Max George A.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200132
Subject(s) - chemistry , halogenation , nitro , indole test , medicinal chemistry , organic chemistry , stereochemistry , alkyl
Preparation of the title compound has been achieved by a modification of the Reissert indole synthesis, starting with 2‐nitro‐3‐methyl‐4‐cyanoanisole ( 3 ), and homologation of the CN group of the resulting 4 ‐cyano‐7‐methoxyindole. The starting material 3 was prepared by bromination of 2‐nitro‐3‐methylphenol, and the structure of the bromination product was verified chemically.