Nitrogen bridgehead compounds, Part  31    1 H and  13 C NMR study of tetra‐ and octahydro‐11 H ‐pyrido[2,1‐ b ]quinazolin‐11‐ones | Zendy

Hermecz István | Zendy; Podányi Benjamin | Zendy; Mészáros Zoltán | Zendy; Kökösi József | Zendy; Szász György | Zendy; Tóth Gábor | Zendy

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Nitrogen bridgehead compounds, Part 31 1 H and 13 C NMR study of tetra‐ and octahydro‐11 H ‐pyrido[2,1‐ b ]quinazolin‐11‐ones

Author(s) -

Hermecz István,

Podányi Benjamin,

Mészáros Zoltán,

Kökösi József,

Szász György,

Tóth Gábor

Publication year - 1983

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570200121

Subject(s) - chemistry , derivative (finance) , conformational isomerism , methyl group , tetra , stereochemistry , nuclear magnetic resonance spectroscopy , nitrogen , group (periodic table) , medicinal chemistry , molecule , organic chemistry , financial economics , economics

Conformational analysis of some tetra‐and octahydro‐11 H ‐pyrido[2,1‐ b ]quinazolin‐11‐ones 1‐3 by 1 H and 13 C nmr revealed that the 9‐methyl‐6,7,8,9‐tetrahydro derivative exists mainly in the conformation containing the methyl group in a quasi‐axial orientation. Of the 1,2,3,4,5,6,7,8‐octahydro compounds, the 9‐methyl derivative 3e contains the methyl group in a quasi‐axial position, while that in the 7‐methyl and the 8‐methyl derivatives 3c,d is in the equatorial position, and the 6‐methyl derivative 3b is a mixture of the two conformers.

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