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Acid catalyzed chlorination of pyrrole with N ‐chloroacetanilide
Author(s) -
de Rosa Michael
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190673
Subject(s) - chemistry , pyrrole , acetic acid , catalysis , medicinal chemistry , organic chemistry
The chlorination of pyrrole with N ‐chloroacetanilide was catalyzed by acetic acid. Transfer of Cl + occurred directly to the α and β positions of pyrrole and a mixture of 2‐chloro‐, 3‐chloro‐ and 2,5,‐dichloropyrrole was formed. The α↗β ratio was 10:1 under competitive conditions.