Premium
Regioselective synthesis of 3‐hydroxyisoxazoles and 5‐isoxazolones from β‐amino α,β‐unsaturated esters
Author(s) -
Kashima Choji,
Konno Yumiko,
Yoshiwara Nobutoshi,
Tajima Tadakuni
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190657
Subject(s) - chemistry , regioselectivity , isoxazole , substituent , yield (engineering) , hydroxylamine hydrochloride , hydroxylamine , hydrochloride , organic chemistry , catalysis , materials science , metallurgy
The regioselective synthesis of 3‐hydroxyisoxazoles and 5‐isoxazolones is accomplished by the reaction of β‐amino α,β‐unsaturated esters with hydroxylamine hydrochloride in the presence of appropriate bases. The total yield of isoxazole derivatives is sensitively influenced on the β‐substituent group of the esters.