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Synthesis of Δ 1[9] ‐ and/or Δ 8[9] ‐dehydroindolizidines and related compounds
Author(s) -
Miyano Seiji,
Fujii Shinichiro,
Yamashita Osamu,
Toraishi Naoko,
Sumoto Kunihiro
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190642
Subject(s) - chemistry , distillation , lime , butyric acid , organic chemistry , radiochemistry , metallurgy , materials science
A facile synthesis of Δ 1[9] ‐ and/or Δ 8[9] ‐dehydroindolizidine and related compounds, consisting of dry distillation of γ‐( N ‐2‐piperidinonyl)butyric acid over soda‐lime, is described. Reductions of these dehydroindolizidines and stereochemistry of 1‐methylindolizidine are also described.