1‐Alkyl‐4‐aryl‐3,4‐dihydro‐2(1 H )‐quinazolinones and thiones. Synthesis and  1 H‐NMR spectra | Zendy

Houlihan William J. | Zendy; Cooke George | Zendy; Denzer Max | Zendy; Nicoletti Joseph | Zendy

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1‐Alkyl‐4‐aryl‐3,4‐dihydro‐2(1 H )‐quinazolinones and thiones. Synthesis and 1 H‐NMR spectra

Author(s) -

Houlihan William J.,

Cooke George,

Denzer Max,

Nicoletti Joseph

Publication year - 1982

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570190639

Subject(s) - chemistry , methanesulfonic acid , thiourea , alkyl , aryl , aldehyde , isopropyl , carbon 13 nmr , medicinal chemistry , nmr spectra database , proton nmr , organic chemistry , spectral line , catalysis , physics , astronomy

A series of 1‐alkyl‐4‐aryl‐3,4‐dihydro‐2(1 H )‐quinazolinones and thiones were prepared by a modification of the Pictet‐Spengler reaction that involves treatment of an N ‐alkyl‐ N ‐arylurea or thiourea with an aryl aldehyde in the presence of methanesulfonic acid. The 1 H‐nmr spectra of several of these compounds gave rise to unusual OCH 2 O and isopropyl signals.

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