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Synthesis of 2,3,3a,8a‐tetrahydroindeno[2,1‐ b ]pyrrole derivatives
Author(s) -
Crooks Peter A.,
DeSimone Francesco,
Ramundo Eliseo
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190635
Subject(s) - chemistry , pyrrole , ninhydrin , medicinal chemistry , catalysis , hydride , organic chemistry , combinatorial chemistry , metal , biochemistry , amino acid
A new entry into the 2,3,3a,8a‐tetrahydroindeno[2,1‐ b ]pyrrole system, 1 , has been investigated. 2,3,3a,8a‐Tetrahydro‐3a,8a‐dihydroxy‐1‐methylindeno[2,1–6]pyrrole‐2,8‐dione, 3 , formed from the reaction of ninhydrin and N ‐methylacetamide has been subjected to catalytic hydrogenation, hydride reduction, and chlorination reactions to afford a variety of substituted derivatives of 1 .
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