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New tetracyclic ring systems. Synthesis of 1 H ‐oxazolo[5,4,3‐ kl ]phenothiazines and [1,4]oxazino[2,3,4‐ kl ]phenothiazines
Author(s) -
Nodiff Edward A.,
Taunk Prakash C.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190611
Subject(s) - chemistry , phenothiazine , derivative (finance) , chloroacetyl chloride , ring (chemistry) , sulfoxide , smiles rearrangement , stereochemistry , medicinal chemistry , organic chemistry , medicine , chloride , financial economics , economics , pharmacology
1‐Hydroxyphenothiazine was converted to 1 H ‐oxazolo[5,4,3‐ kl ]phenothiazin‐1‐one, 1 H ‐oxazolo[5,4,3‐ kl ]‐phenothiazine‐1‐thione,[1,4]oxazino[2,3,4‐ kl ]phenothiazin‐1(2 H )one and [1,4]oxazino[2,3,4‐ kl ]phenothiazine‐1,2‐dione. Also prepared from 1‐hydroxyphenothiazine were the N ‐chloroacetyl derivative, the O ‐chloroacetyl derivative, the N,O ‐di(chloroacetyl) derivative and the sulfoxide.