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Synthesis of potential antineoplastic agents. XXVII. (Reissert compound studies. XLIV.). The ellipticine reissert compound as an intermediate in the syntheses of ellipticine analogs
Author(s) -
Popp Frank D.,
Veeraraghavan Seshadri
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190603
Subject(s) - chemistry , alkylation , hydrochloride , stereochemistry , hydrolysis , amidine , combinatorial chemistry , organic chemistry , catalysis
Ellipticine and a number of ellipticine analogs were converted to Reissert compounds. Alkylation of the 6‐benzylellipticine Reissert compound gave a series of 1‐substituted‐6‐benzylellipticines. 1‐Cyanoellipticine, obtained through the Reissert compound, was hydrolyzed to ellipticine‐1‐carboxamide hydrochloride which was active against P388 lymphocytic leukemia. Other aspects of the chemistry of the ellipticine Reissert compound are presented.