Premium
Some reactions of 1‐methyl‐1,2,3,4‐tetrahydropyridine with organic azides. Synthesis of 1‐methylpiperidylidene‐2‐sulfon(cyan)amides
Author(s) -
Warren B. K.,
Knaus E. E.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190562
Subject(s) - chemistry , cyan , yield (engineering) , medicinal chemistry , hydrolysis , organic chemistry , visual arts , art , materials science , metallurgy
The 1,3‐dipolarcycloaddition reaction of 1‐methyl‐1,2,3,4‐tetrahydropyridine ( 1 ) with organic azides 2 affords 1‐methylpiperidylidene‐2‐sulfon(cyan)amides 4 in high yield. The reaction proceeds via a 2,3,4,9‐tetrazabicyclo[4.3.0]non‐3‐ene intermediate. Acid hydrolysis of 4d gives rise to 1‐methyl‐2‐piperidone.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom