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Synthesis of 2‐amino‐6‐chloro‐ and 2,6‐diammopunne 3‐oxides
Author(s) -
Scheinfeld Israel,
Parham James C.,
Brown George Bosworth
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190551
Subject(s) - chemistry , oxide , halogen , purine , amino acid , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry , alkyl , enzyme
Abstract N ‐Oxidation of 2‐amino‐6‐chloropurine to the 3‐oxide provided a convenient intermediate for the synthesis of 2‐amino‐6‐substituted purine 3‐oxides, including the previously unavailable 2,6‐diaminopurine 3‐oxide. Thiation of the 6‐halogen was accompanied by reduction of the N ‐oxide. The properties of the 1‐ and 3‐oxides of 2,6‐diaminopurine are compared.