Synthesis of 4(3 H )‐quinazolinones from derivatives of methyl 2‐isothiocyanatobenzoate | Zendy

Dean William D. | Zendy; Papadopoulos Eleftherios P. | Zendy

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Synthesis of 4(3 H )‐quinazolinones from derivatives of methyl 2‐isothiocyanatobenzoate

Author(s) -

Dean William D.,

Papadopoulos Eleftherios P.

Publication year - 1982

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570190527

Subject(s) - chemistry , thiocarbamate , reagent , yield (engineering) , nucleophile , tricyclic , amide , primary (astronomy) , ring (chemistry) , medicinal chemistry , stereochemistry , organic chemistry , materials science , physics , astronomy , metallurgy , catalysis

Ethyl N ‐(2‐methoxycarbonylphenyl)thiocarbamate ( 2), N ‐(2‐ethoxycarbonylphenyl)‐4‐methoxythiobenz‐amide ( 3b ), and 2‐(4‐methoxyphenyl)‐4 H ‐3,1‐benzothiazin‐4‐one ( 4a ), react with nucleophilic reagents containing at least one primary amino group to yield a variety of 2‐substituted and 2,4‐disubstituted 4(3 H )quinazolinones, as well as some tricyclic and tetracyclic products.

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