A convenient synthesis of  N ‐aryl‐1,2‐dihydro‐2‐oxo‐3‐pyridinecarbox‐amides,  N ‐aryl‐ N ‐methyl‐1,2‐dihydro‐2‐oxo‐3‐pyridinecarboxamides and their 1‐methyl ( O ‐methyl)‐derivatives | Zendy

Cativiela C. | Zendy; Fernandez J. | Zendy; Melendez E. | Zendy

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A convenient synthesis of N ‐aryl‐1,2‐dihydro‐2‐oxo‐3‐pyridinecarbox‐amides, N ‐aryl‐ N ‐methyl‐1,2‐dihydro‐2‐oxo‐3‐pyridinecarboxamides and their 1‐methyl ( O ‐methyl)‐derivatives

Author(s) -

Cativiela C.,

Fernandez J.,

Melendez E.

Publication year - 1982

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570190522

Subject(s) - chemistry , aryl , tautomer , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , alkyl

A new and versatile method for the preparation of the isonixine analogues, N ‐aryl‐1,2‐dihydro‐2‐oxo‐3‐pyridinecarboxamides and N ‐aryl‐ N ‐methyl‐1,2‐dihydro‐2‐oxo‐3‐pyridinecarboxamides is described via the selective chlorination of 2‐hydroxynicotinic acid. In order to prepare these new compounds, the chemistry of the methyl‐blocked forms of each tautomer is discussed.

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