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A convenient synthesis of N ‐aryl‐1,2‐dihydro‐2‐oxo‐3‐pyridinecarbox‐amides, N ‐aryl‐ N ‐methyl‐1,2‐dihydro‐2‐oxo‐3‐pyridinecarboxamides and their 1‐methyl ( O ‐methyl)‐derivatives
Author(s) -
Cativiela C.,
Fernandez J.,
Melendez E.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190522
Subject(s) - chemistry , aryl , tautomer , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , alkyl
Abstract A new and versatile method for the preparation of the isonixine analogues, N ‐aryl‐1,2‐dihydro‐2‐oxo‐3‐pyridinecarboxamides and N ‐aryl‐ N ‐methyl‐1,2‐dihydro‐2‐oxo‐3‐pyridinecarboxamides is described via the selective chlorination of 2‐hydroxynicotinic acid. In order to prepare these new compounds, the chemistry of the methyl‐blocked forms of each tautomer is discussed.