Synthesis of 1,2′,3,3′,5′,6′‐hexahydro‐3‐phenylspiro[isobenzofuran‐1,4′‐thiopyrans]  and 1,2′,3,3′,5′,6′‐hexahydro‐3‐phenylspiro‐[isobenzofuran‐1,4′‐pyrans] | Zendy

Bauer Victor J. | Zendy; Ong Helen H. | Zendy; Kosley Raymond W. | Zendy

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Synthesis of 1,2′,3,3′,5′,6′‐hexahydro‐3‐phenylspiro[isobenzofuran‐1,4′‐thiopyrans] and 1,2′,3,3′,5′,6′‐hexahydro‐3‐phenylspiro‐[isobenzofuran‐1,4′‐pyrans]

Author(s) -

Bauer Victor J.,

Ong Helen H.,

Kosley Raymond W.

Publication year - 1982

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570190518

Subject(s) - isobenzofuran , chemistry , thiopyran , ring (chemistry) , pyran , ether , stereochemistry , medicinal chemistry , organic chemistry

The 1,2′,3,3′,5′,6′‐hexahydro‐3‐phenylspiro[isobenzofuran‐1,4′‐thiopyran] ring system ( 2a ) has been prepared from o ‐bromobenzoic acid. The 1,2′,3,3′,5′,6′‐hexahydro‐3‐phenylspiro[isobenzofuran‐1,4′‐pyran] ring system ( 3a ) has been prepared from 2‐bromobenzhydrol methyl ether. Several 3‐(dimethylaminoalkyl) derivatives of both 2a and 3a were prepared by lithiation followed by alkylation.

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