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Some reactions of mono substituted pyrazine monoxides
Author(s) -
Ohta Akihiro,
Watanabe Tokuhiro,
Akita Yasuo,
Yoshida Maki,
Toda Suzumi,
Akamatsu Tomoko,
Ohno Hiroko,
Suzuki Akiko
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190517
Subject(s) - chemistry , acetic anhydride , pyrazine , ring (chemistry) , chloride , phosphoryl chloride , medicinal chemistry , organic chemistry , acetic acid , acetyl chloride , oxide , catalysis
The reactions of the monoxides of propylpyrazine and phenylpyrazine with phosphoryl chloride or acetic anhydride were investigated. Except in the case of the reaction of 2‐propylpyrazine 1‐oxide with acetic anhydride, chlorination or acetoxylation occurred on the pyrazine ring in all cases; moreover, these reactions occurred preferentially at the position poorest in π‐electron density. The N ‐oxidation and the successive chlorination of monochloro‐phenylpyrazines were also investigated, and the structures of the products were confirmed.