The synthesis of N ‐[2‐(D‐glucos‐3‐ O ‐yl)propionyl]‐l‐alanine and N ‐[(d‐glucos‐3‐ O ‐yl)acetyl]‐l‐alanine

N ‐[2‐(D‐Glucos‐3‐ O ‐yl)propionyl]‐L‐alanine ( 7a ) was synthesized, which has a glucose residue instead of N ‐acetylglucosamine residue in the muramyl peptide. N ‐[(D‐Glucos‐3‐ O ‐yl)acetyl]‐L‐alanine ( 7b ) was also synthesized as a glycolyl analog of 7a in order to determine the relationship between the structure of propionyl moiety in the carbohydrate analog ( 7a ) and the adjuvant activity. These simple analogs are compounds prepared for the purpose of introduction into a synthetic polymer with the view of producing polymeric drugs.