Premium
Reactions of 3‐acetyltropolone and its methyl ethers with aminoguanidine
Author(s) -
Jin ZhongTian,
Imafuku Kimiaki
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190457
Subject(s) - chemistry , acetic acid , medicinal chemistry , organic chemistry
3‐Acetyltropolone ( 1 ) reacted with aminoguanidine to afford its guanylhydrazone ( 3 ). The reaction of 3‐acetyl‐2‐methoxytropone ( 2a ) gave 4‐methyl‐1(2 H )‐phthalazinone ( 5 ), while the reaction of 7‐acetyl‐2‐methoxytropone ( 2b ) gave its guanylhydrazone ( 6 ) and 3‐methyl‐1,8‐dihydrocycloheptapyrazol‐8‐one ( 4 ). The guanylhydrazones ( 3 and 6 ) were easily cyclized to 4 by heating in acetic acid.