Premium
Imino‐bridged heterocycles. I. A derivative of benzo[5,6]cyclohepta[1,2‐ b ]pyridin‐5,11‐imine
Author(s) -
Halczenko W.,
Shepard K. L.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190456
Subject(s) - chemistry , imine , tricyclic , amine gas treating , anhydrous , derivative (finance) , ring (chemistry) , stereochemistry , medicinal chemistry , organic chemistry , catalysis , financial economics , economics
The current interest in structures that contain a tricyclic framework with a nitrogen bridged central ring has prompted us to examine the synthesis of imino‐bridged benzocycloheptapyridines. Treatment of 5,6‐trans‐dibromobenzo[5,6]cyclohepta[1,2‐ b ]pyridin‐11‐one with anhydrous methyl amine in THF produced 6‐β‐bromo‐5,6‐dihydro‐11α‐hydroxy‐12‐methyl‐11 H ‐benzo[5,6]cyclohepta[1,2‐ b ]pyridin‐5,11‐imine, the first example of the desired bridged derivatives.