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An alternative synthesis of tiopinac
Author(s) -
Thurber T. Craig,
Prince Anthony,
Halpern Otto
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190455
Subject(s) - chemistry , acetic acid , stereochemistry , combinatorial chemistry , pharmacology , organic chemistry , medicine
Tiopinac (1) [6, 11‐dihydro‐11‐oxodibenzo[ b,e ]thiepin‐3‐acetic acid, ( 1 )] has shown a high degree of antiinflammatory activity and a low incidence of side effects in animals ( 2 ). On the basis of these results, Tiopinac was chosen for human evaluation in 1978 (2a).