Premium
Preparation of 7‐aminoquinolines as candidate antiparasitic agents
Author(s) -
Markovac Anica,
Wu GengShuen,
Lamontagne Maurice P.,
Blumbergs Peter,
MengSheng Ao
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190424
Subject(s) - chemistry , antiparasitic , aminoquinolines , antiparasitic agent , plasmodium berghei , combinatorial chemistry , pharmacology , stereochemistry , malaria , biology , immunology , medicine , pathology
A series of ten 7‐quinolinediamines were prepared and evaluated for potential antiparasitic activity against P. berghei, P. cynomolgi, L. donovani and T. rhodesiense. Compounds 1d and 8 showed activity being slightly effective against L. donovani in hamsters.