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Convenient syntheses of 3,6‐dialkyl‐1,4‐dihydroxy‐2,5‐dioxopiperazines
Author(s) -
Ohta Akihiro,
Yamamoto Fusako,
Arimura Yasuhiko,
Watanabe Tokuhiro
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190415
Subject(s) - chemistry , diastereomer , stereochemistry , organic chemistry
Abstract Some 3,6‐dialkyl‐1,4‐dihydroxy‐2,5‐dioxopiperazines were conveniently prepared from the corresponding 3,6‐dialkyl‐2,5‐dichloropyrazines via their 1,4‐dioxides and 3,6‐dialkyl‐2,5‐dihydroxypyrazine 1,4‐dioxides. On the basis of the examination of pmr, tlc, and glc of the 2,5‐dioxopiperazines derived from the products, it was clarified that all the products were cis ‐diastereomers.