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Pyridiniums as potential synthetic substitutes for nitrogen mustards
Author(s) -
Katritzky Alan R.,
Burgess Kevin,
Patel Ranjan C.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190408
Subject(s) - pyridinium , chemistry , nucleophile , alkyl , nitrogen , organic chemistry , pyridinium compounds , combinatorial chemistry , catalysis
Dialkylamino‐alkyl primary amines 1b and 2b are converted by pyrylium salts into the corresponding pyridinium derivatives. The pyridinium salts act as aminoalkylating agents for representative O‐, S‐, N ‐, and C ‐nucleophiles and are potentially safe substitutes for nitrogen mustards in the reactions.
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