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1‐Phenyl‐6,7‐disubstituted‐aminopropyl)‐1,2,3,4‐tetrahydroisoquinolines as possible antituberculer agents
Author(s) -
Kumar P.,
Dhawan K. N.,
Kishor K.,
Bhargava K. P.,
Satsangi R. K.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190349
Subject(s) - chemistry , benzaldehyde , mycobacterium smegmatis , condensation , stereochemistry , medicinal chemistry , in vitro , organic chemistry , catalysis , biochemistry , mycobacterium tuberculosis , medicine , tuberculosis , physics , pathology , thermodynamics
The Condensation of 3,4‐disubstituted phenylethylamine and benzaldehyde furnished l‐phenyl‐6,7‐disubstituted‐1,2,3,4‐tetrahydroisoquinolines l. which on reaction with 1,3‐dibromopropane gave l‐phenyl‐6,7‐disubstituted‐2‐(3‐bromoprophyl)‐1,2,3,4‐tetrahydroisoquinolines 2. The reaction of 2 with different secondary amines resulted in the synthesis of 3. The compounds 3 were screened for their in vitro antituberculer activity against Mycobacterium smegmatis , and some of them have been found to be total inhibitors of M. Smegmatis