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Studies on pyrazines, 8 . An improved syntheses of 2‐amino‐3,5‐dibromo‐ and 2‐amino‐5‐bromopyrazines
Author(s) -
Sato Nobuhiro
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190347
Subject(s) - chemistry , halogenation , bromine , yield (engineering) , pyridine , reagent , chloroform , iodine , organic chemistry , medicinal chemistry , metallurgy , materials science
The titled dibromopyrazine ( 2 ) was prepared in 54% yield by the modified procedure for bromination of 2‐aminopyrazine ( 1 ) using bromine and pyridine in chloroform solution. Similarly, 2‐amino‐5‐bromopyrazine ( 3 ) was directly prepared in 36% yield by bromination using 1.2 equivalents of the above reagents.