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Heterocycles from phosphonium salts: A facile method for modification of the 4(5)‐methyl group of thiazoles
Author(s) -
Lee Webb R.,
Lam Bing L.,
Lewis Joseph J.,
Wellman George R.,
Berkoff Charles E.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190336
Subject(s) - phosphonium , chemistry , thiourea , yield (engineering) , condensation , organic chemistry , phosphonium salt , combinatorial chemistry , salt (chemistry) , materials science , physics , metallurgy , thermodynamics
Thiazolyl phosphonium salts, formed from the condensation of acyl vinyl phosphonium salts with thioamides and thiourea, are readily functionaitzed in high yield. The sequence represents a useful general synthesis of multifunctional thiazoles.
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