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Potential anticonvulsants. V. The condensation of isatins with C ‐acetyl heterocyclic compounds
Author(s) -
Popp F. D.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190327
Subject(s) - isatin , chemistry , condensation , organic chemistry , medicinal chemistry , thermodynamics , physics
A number of C ‐acetyl heterocyclic compounds were condensed with isatin and substituted isatins to give a series of 3‐hydroxy‐3‐substituted oxindoles. The products from 2‐acetylfuran and isatin, 2‐acetylthiophene and isatin, and 2‐acetylpyridine and 1‐methylisatin were active at 100 mg/Kg in the maximal electroshock seizure test.