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Syntheses and reactions of some 2,3‐disubstituted pyrazine monoxides
Author(s) -
Ohta Akihiro,
Masano Sawako,
Iwakura Sachiko,
Tamura Akiko,
Watahiki Hiroko,
Tsutsui Mayumi,
Akita Yasuo,
Watanabe Tokuhiro,
Kurihara Teruo
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190304
Subject(s) - pyrazine , chemistry , acetic anhydride , organic chemistry , chloride , benzoyl chloride , medicinal chemistry , acetic acid , phosphoryl chloride , catalysis
The reactions of 2,3‐dimethyl‐ ( 4 ), 2,3‐diphenyl‐ ( 6 ), and 2‐methyl‐3‐phenyl‐pyrazine monoxides ( 8 and 9 ) with phosphoryl chloride and acetic anhydride resulted in giving monochloro‐ and monacetoxy‐pyrazines in almost all cases. However, the reaction of 6 with acetic anhydride afforded exceptionally a diacetoxydihydro‐pyrazine. These products were converted further to hydroxy or dichloro derivatives.