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Heterocycles. Part I. A new route to the synthesis of substituted 2‐aminopyrimidines
Author(s) -
ElRayyes N. R.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190240
Subject(s) - chemistry , guanidine , condensation , alkyl , aryl , organic chemistry , medicinal chemistry , combinatorial chemistry , stereochemistry , physics , thermodynamics
Heterocyclic aldehydes (A) reacted with alkyl aryl ketones (B) to give the corresponding 1,3‐diaryl‐2‐propen‐1‐ones (Ia‐1). Condensation of these chalcones with guanidine produced the corresponding 2‐amino‐4,6‐diarylpyrimidines (IIa‐1). The structure of all products was substantiated by chemical and spectroscopic methods.