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Fused‐ s ‐triazino heterocycles IX . 1,3,4,6,9b‐pentaazaphenalenes and 1,3,6,9b‐tetraazaphenalenes: Amino and alkoxy derivatives
Author(s) -
Shaw John T.,
Coffindaffer Timothy W.,
Stimmel Julie B.,
Lindley Patricia M.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190228
Subject(s) - chemistry , alkoxy group , nucleophile , base (topology) , medicinal chemistry , catalysis , group (periodic table) , organic chemistry , mathematical analysis , alkyl , mathematics
The trichloromethyl group served as a useful leaving group in nucleophilic displacement reactions by a variety of substituted amines and alcohols (the latter under base catalysis) on 2‐trichloromethyl‐5‐methyl‐1,3,4,6,9b‐pentaazaphenalene ( 1a ) and 2‐trichloromethyl‐4‐cyano‐1,3,6,9b‐tetraazaphenalene ( 2a ). The reaction conditions were mild and the yields of the corresponding 2‐substituted amino and alkoxy derivatives were generally good.