Premium
Reactions between 4‐hydroxy‐6‐methyl‐2‐pyrone and aldehydes both in the absence and the presence of added thiols
Author(s) -
de March P.,
MorenoMañas M.,
Pi R.,
Trius A.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190223
Subject(s) - chemistry , knoevenagel condensation , pyrone , organic chemistry , medicinal chemistry , catalysis
Aldehydes react with 4‐hydroxy‐6‐methyl‐2‐pyrone, 2 , under Knoevenagel conditions to afford very elec‐trophilic intermediates, which can be trapped by more 2 or thiols to give dilactones 3 or monolactones 4.