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Synthesis and reactivity of 4‐substituted‐2,3‐dihydrobenzo‐1,4‐thiazines
Author(s) -
Florio Saverio,
Leng John L.,
Stirling Charles J. M.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190203
Subject(s) - chemistry , thiazine , ring (chemistry) , bromide , reactivity (psychology) , derivative (finance) , condensation , medicinal chemistry , stereochemistry , organic chemistry , medicine , alternative medicine , pathology , physics , financial economics , economics , thermodynamics
A series of derivatives of 4 H ‐2,3‐dihydrobenzo‐1,4‐thiazine has been prepared. 4‐Acetyl‐2,3‐dihydrobenzo‐1,4‐thiazine undergoes self‐condensation by n ‐butylmagnesium bromide affording the corresponding 4‐aceto‐acetyl‐2,3‐dihydrobenzo‐1,4‐thiazine, which, is converted to 5 H ‐1,4‐thiazino[2,3,4‐ if ]quinolin‐5‐one. Halogena‐tion of the acetyl derivative takes place at the position 2 of the heterocyclic ring and oxidation leads to 1‐oxides and 1,1‐dioxides.