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Synthesis of 2‐alkoxy‐6‐aryl‐5‐cyano‐4(3 H )‐pyrimidinones
Author(s) -
Pérez Miguel A.,
Soto José L.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190134
Subject(s) - chemistry , pyrimidinones , sodium methoxide , cyanamide , aryl , alkoxy group , methanol , hydrolysis , acid hydrolysis , organic chemistry , medicinal chemistry , alkyl
The reaction of methyl 3‐aryl‐2‐cyano‐3‐methoxypropenoates 1 with cyanamide and sodium methoxide in methanol afforded after acid hydrolysis the methyl 3‐[(aminocarbonyl)amino]‐3‐aryl‐2‐cyanopropenoates 4 . By performing the reaction in higher boiling alcohols the 2‐alkoxy‐6‐aryl‐5‐cyano‐4(3 H )‐pyrimidinones 2 were obtained in good yields.