Premium
Functionalization at C‐5 and at the C‐6 methyl group of 4‐methoxy‐6‐methyl‐2‐pyrone
Author(s) -
Bacardit R.,
MorenoMañas M.,
Pleixats R.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190130
Subject(s) - chemistry , pyrone , dehydroacetic acid , phosphonium , methyl group , surface modification , stereochemistry , organic chemistry , medicinal chemistry , group (periodic table)
A new entry to C‐5 substituted 4‐hydroxy‐6‐methyl‐2‐pyrones has been achieved. The best conditions to prepare the monobromo and the dibromo derivatives at C‐3 and the C‐6 methyl group of the title pyrone have been defined. The synthetic applicability of the phosphonium salts at CH 3 ‐C‐6 of both 4‐methoxy‐6‐methyl‐2‐pyrone, 5 , and dehydroacetic acid, 2 , has also been evaluated.